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However, we note that, as discussed in section III.A.2.a of this proposed rule, CMS already has a policy in place for multiple source drugs for which the absence of ASP data would result in a significant change (that is, a 10 percent or greater change) in the ASP payment limit compared to the payment limit of the previous quarter, as finalized in the CY 2011 PFS final rule (75 FR 73461 through 73465)

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Dosage increase of ZYBAN may be necessary when coadministered with ritonavir, lopinavir, or efavirenz [see Clinical Pharmacology (12.3)] but should not exceed the maximum recommended dose

To avoid having to consult dental emergency in Lausanne or elsewhere in Switzerland, prevention remains the best solution

A survey revealed that less than 25% of hepatologists refer smokers to specialized cessation units, indicating a gap in integrating smoking cessation into routine liver care [151]