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[114] In the United States, its retail version sold 550,000 copies and earned $15.7 million by August 2006, making it the 22nd best-selling PC game in the country between January 2000 and August 2006

The aerosols produced by e-cigarettes can contain harmful chemicals that disrupt this balance, potentially leading to infections or unpleasant odors

Smokers have been more likely than non-smokers to die during previous influenza epidemics and are more prone to chronic obstructive pulmonary disease (COPD)

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Nicotine, however, alters this response, he said