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E-cigarettes have generally been accepted as a healthier alternative to tobacco use even the American Cancer Society publicly recognized this in a statement that read, some smokers, despite firm clinician advice, will not attempt to quit smoking cigarettes and will not use FDA approved cessation medicationsthese individuals should be encouraged to switch to the least harmful form of tobacco product possible. Treating cigarettes and e-cigarettes equally under the Tobacco 21 laws misleads consumers into believing cigarettes and e-cigarettes are the same product with the same hazards

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Hornikx et al

Pulmonary cells such as lung epithelial cells or alveolar macrophages could have different responses to CSE in terms of cellular NLRP3 protein levels, while monocytes or monocyte-derived macrophages have decreased NLRP3 protein levels upon exposure to CS, leading to immunosuppression [171]

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