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Population-level counterfactual trend modelling to examine the relationship between smoking prevalence and e-cigarette use among US adults

Nicotine has known pathological effects, mainly related to the excessive release of catecholamines, endothelial dysregulation and increased insulin resistance.90 Nicotine in electronic cigarettes has been shown to increase heart rate after overnight abstinence.91 Regarding lipid metabolism, nicotine in electronic cigarettes has been shown to increase the amount of circulating saturated fatty acids, decreasing the content of unsaturated fatty acids and inducing insulin resistance

The heated tobacco market is dominated by products from the cigarette industry, which has historically acted to distort science into the harm of cigarettes

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