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Mortality and morbidity burden associated with smoking: evidence from a 1.6 million cohort in Hong Kong Boyuan Wang, Tingting Chen, Ming Hin Lee, Ka Hung Chan, Sophia Siu Chee Chan, Ian Chi Kei Wong, Eric Yuk Fai Wan BMC Medicine 31

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The study also found that nicotine produced these negative effects by stimulating the ion channel transient receptor potential ankyrin 1 (TRPA1)

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