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changes in normal bodily functionsthe user will experience withdrawal from the drug upon cessation of use an emotional, rather than physical, need for the drug and may use the drug to relieve psychological distress linked to physiological dependence, and it occurs when a person requires more and more drug to achieve effects previously experienced at lower doses a variety of negative symptoms experienced when drug use is discontinued a drug that tends to suppress central nervous system activity

Despite this knowledge, quitting can be hard as nicotine is addictive

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As the UC patients were older than CD patients (diagnosed age: 42 vs 27 years-old), the UC matched control group was older than CD mated control group

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