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22 The absence of ABCA1 or ABCG1 in alveolar type II epithelial cells leads to cholesterol overload, impairing surfactant function, and resulting in severe surfactant protein and lipid accumulation

allows valid comparisons

L i , the lung cancer rates by smoking group, can be estimated based on the following equations: These solve directly to give: or alternatively The variance of the logarithm of the rate estimate, L i , can then be estimated approximately as: The inverse of var log L i can be used as a weighting factor in meta-analysis

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