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An additional feature of e-cigarettes that is now often manipulated is nicotine type, based on the ratio of the R- and S-nicotine isomers: synthetic nicotine contains a mixture of both R- and S-nicotine, whereas traditional tobacco-derived nicotine contains primarily S-nicotine 15

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Smoking, fertility & pregnancy: The facts Smoking is associated with a number of health issues, including heart disease and cancers, among other problems