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These specific chemical compounds are widely recognized by the global medical community as some of the most potent carcinogens on the planet

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Flue-curing preserves naturally occurring sugars within the leaf, contributing to the blends characteristic chemical composition and lower bitterness relative to Burley-dominant structures

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They induce the production of free radicals, which cause lipid peroxidation (or degradation) and can lead to an inhibition of hair follicle growth, but also to a degradation of hair pigments, thus causing discoloration or alteration of the original hue