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Assessment of adverse events All adverse events will be reported in detail in an observation table (Table 1), including the type of event, the extent of symptoms or diseases, the date of onset, frequency, duration, the remission date, treatment measures, treatment process, results, and follow-up, for evaluation of any correlations between adverse reactions and A&AA or NRT

Usage Pattern: Each IQOS session is discrete, limited to one HEETS stick, similar to a cigarette's usage

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Based on prior research experience, we hypothesized the optimal number of topics to be between 5 and 50

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