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J Adolesc Health 73(3):437444 Perez A, Valencia S, Jani PP, Harrell MB (2024) Use of electronic nicotine delivery systems and age of asthma onset among US adults and youths

Systems toxicology analyses detected biological effects of nicotine exposure, which included up-regulation of the xenobiotic-metabolizing enzymes CYP1A1 and FMO3 in the lung and metabolic effects, likely interlinked with a generalized stress response to nicotine present in the exposure aerosols [34]

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The National Institute on Drug Abuse reported that in 2021, the proportion of adults aged 19-30 surveyed that reported past year marijuana use was 43%, up from 29% in 2011

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