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45 The findings that dual users of cigarettes and e-cigarettes have worse HRQoL than 5-year cessation may reflect the fact that these persons tend to be heavier, more dependent smokers 46 compared to 5-year cessation, many of whom may not have been heavy cigarette smokers to begin with

And the ancient Greeks believed that people had fire only thanks to the efforts of the titan Prometheus

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The fact that numerous attempts in this direction have been made, and yet thee is no substitute for tobacco and no de-nicotinized tobacco in general use, is itself a sufficient answer to the question