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These observations combined suggest that smoking might elicit effects on DNA methylation independent of background risk associated with an individuals genetic or environmental propensity for smoking

Smoking prevalence was also described in non-physicians in 30 studies [24,39,40,52,69,74,79,86,91,99,102,104,105,110,113,125,129,133,135,139,143,151,161,162,176,185,195,197,202,235]

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Significantly higher abundance of Streptococcus emerged as a marker for the healthy oral microbiome, which was also supported by comparative analysis of other OSCC microbiome cohorts

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