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Stearns said he and co-owner Ryan Botner were optimistic it could work, but the brand's growth has outpaced their wildest expectations

Handling missing data Five participants had missing outcome data for all outcomes, 626 participants had complete outcome data for the primary outcome and were analysed by original assigned groups (see Fig

Dark air-cured tobacco is cured mainly through natural air circulation rather than the heated-air method used for FCV

Snus (pronounced like "snoose") is a finely ground form of snuff that originated in Norway and Sweden that comes in small tins