Section Contents Eliminate Tobacco Use Maintain a Healthy Weight, Eat a Healthy Diet, and Stay Active Limit Alcohol Consumption Protect Skin from UV Exposure Prevent and Eliminate Infection with Cancer-causing Pathogens Reduce Risk of Diabetes Be Cognizant of Reproductive and Hormonal Influences Pregnancy and Breastfeeding Hormone Replacement Therapy Limit Exposure to Environmental Risk Factors Decades of research have led to the identification of numerous factors that increase the chance of developing cancer ( Figure 2 )
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How Carcinogens in Cigarette Smoke Cause Lung Cancer The carcinogens in cigarette smoke that are inhaled can be metabolically activated (most notably by cytochrome P450 enzymes in the liver) to intermediate compounds that covalently or (sometimes) directly bind to DNA
Unlike smoking, which primarily affects the lungs, chewing tobacco delivers carcinogens directly to the tissues in the mouth, accelerating the development of oral cancers.A study published in Nature Communications reviewed global data on chewing tobacco use and its health effects
