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We did not find sufficient evidence of a significant association between chewing tobacco use and the risk of ischemic heart disease based on our conservative interpretation of the data that yielded a zero-star risk-outcome association (Table 2)

Retrieved February 18, 2013, from Ono, I

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Nicotine continues to be absorbed into the bloodstream for much longer than for smokers Smokeless tobacco causes oral cancer, esophageal cancer, and pancreatic cancer, and puts the user at risk for heart disease, gum disease, and oral lesions