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Some potentially harmful chemicals have been detected in e-cigarettes, namely nitrosamines, formaldehyde, acetaldehyde, acrolein, metals, and PAHs, which are known or suspected carcinogens

In addition, it discusses additional efficacy endpoints that may be used in NRT drug products that have already demonstrated effectiveness in smoking cessation or reduction of risk of relapse: reduction in urge to smoke, relief of cue-induced craving in former smokers, and relief of withdrawal symptoms not associated with a cessation attempt

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Their best interest