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Conclusions and perspectives CS imposes widespread systemic consequences not only through its direct toxicological insults but also by reshaping microbial ecosystems that are fundamental to host homeostasis

aureus and Corynebacterium xerosis , potentially impacting oral health through transient pathogen colonization [60]

Taken together, the abundance of marker genera in healthy and inflammation-associated oral microbiomes reaffirms the potential impact of smokeless tobacco consumption in the dysbiosis of oral microbiome ( Figure 7 )

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The researchers also found that a marked increase was observed after 1990 in smoking initiation among early adolescent boys and girls, 11 to 15 years old, in all European regions, except among boys in North Europe