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For MVMR, in addition to the multivariable extension of the MR PRESSO global test, we used the multivariable extension of the MR Lasso method, which applies lasso-type penalization to the direct effects of the instruments on the outcome disease: the so-called post-lasso estimate is obtained by performing MR IVW using only those instruments identified as valid instruments (tuning parameter specified at default heterogeneity stopping rule) 89

When estrogen levels fluctuate during perimenopause, they can cause temporary increases in olfactory sensitivity

Long-term damage to the heart and blood vessels can lead to heart failure, cardiomyopathy, and myocarditis

Its also called an abnormal heart rhythm

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