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Section 1871(e)(1)(A) of the Act provides that a substantive change in regulations, manual instructions, interpretative rules, statements of policy, or guidelines of general applicability under Title XVIII of the Act may not apply retroactively unless the Secretary has determined that such retroactive application is necessary to comply with statutory requirements or that failure to apply such policies retroactively would be contrary to the public interest

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RIF induction of CYP3A4 is mediated by an orphan nuclear receptor known as the pregnane X receptor (PXR)

An initial proposal to ban tobacco use entirely was rejected by the players