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Using data collected and updated over a 28-month period by 22,000 ACS volunteers, Hammond and Horn reviewed the smoking histories of healthy 187,766 men, of whom 32,381 never smoked, in 394 counties scattered across the U.S

Given that smoking is an established risk factor for many chronic diseases, these loci could have important applications as objective biomarkers of both current and lifetime smoking exposure and for quantifying risks of smoking-related diseases

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Sometimes tobacco is aged before being blended with other components, or is aged before being packaged