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Heated tobacco products (HTPs) work by warming actual tobacco to a high enough temperature to release a nicotine-containing aerosol, but not so hot that the tobacco burns

However, as discussed below, our Office does not have access to this data due to the lack of adequate subcontractor reporting

Nicotine itself does not have calories

Absent the unlikely situation that the additives would eliminate tobacco smoke's genotoxicity and mutagenicity, the failure to find increased toxicity associated with the additives does not support the conclusion that in vitro mutagenicity and cytotoxicity of the cigarette smoke were not increased by the addition of the ingredients [17]

The FDAs nicotine guidance covers the full safety picture for US adults