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Minor contributions to drug metabolism have been observed in vitro from CYP1A1, CYP2C8, and CYP2C18, though these enzymes are less relevant in vivo due to their lower hepatic expression compared to CYP3A4 (Shimada et al., 1994)

Halitosis (bad breath), in which the breath begins to take on a foul odor, may be present in more severe forms of gingivitis

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This toll continues despite the progress countries have made reducing tobacco use by adopting evidence-based policies as outlined by the WHO Framework Convention on Tobacco Control

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