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The National Cancer Institute (NCI) at the National Institutes of Health puts it succinctly on its website: There is no safe form of tobacco. All kinds of tobacco, whether smoked or not, contain the addictive substance nicotine, and in addition, smokeless tobacco has been found to contain twenty-eight substances that cause cancer
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Evidence supports HIF-1 activation by carbon monoxide through hemoglobin binding and secondary hypoxia, and by nicotine through the activation of a nicotinic acetylcholine receptor (nAChR)-mediated signaling pathway 16,69,70
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