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A case-control study published in Oral Diseases found that smokers were 5.6 times more likely to develop lip pigmentation than non-smokers, with the risk increasing the longer a person smoked.The result is smokers lips that appear darker, duller, and older than they actually are

Nicotine could maintain or restore the function of the cholinergic anti-inflammatory system and thus control the release and activity of pro-inflammatory cytokines, writes Farsalinos

The review authors note that smoking reduction is a promising intervention, particularly when supported by clean nicotine, such as the nicotine used in electronic cigarettes

The generic line was given the brand "Econo Buy" in the early 1990s