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With respect to SSRIs, citalopram is metabolized by CYP 2C19 and 3A4 [33], fluoxetine by 2D6, 3A4 and 2C9 [33], fluvoxamine by 1A2 and 2D6 [33], escitalopram by 2C19, 2D6 and 3A4 [16], and sertraline by 2D6, 3A4, 2C9 and 2C19 [33]
Cigarette smoke damages the nerve endings in the mouth and nose, which can have a numbing effect
If 15 gums of 2 mg per day are not sufficient, as for heavy smokers (more than 20 cigarettes per day), it is preferable to use NICORETTE 4 mg chewable gums, or two gums of 2 mg at the same time
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