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These findings suggest that the observed relationship may be influenced by differences in participant characteristics rather than by e-cigarette use itself

In step 3, following the GRADE approach 192,193 , we quantified risk of bias across six domains, namely, representativeness of the study population, exposure, outcome, reverse causation, control for confounding and selection bias

Bronchoscopy with bronchoalveolar lavage and transbronchial biopsies may be considered in cases where the diagnosis is uncertain or where infection is not fully excluded

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