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HDL levels over 116 mg/dL for men or 135 mg/dL for women cause an increase in the risk of heart disease.[ref] HDL cholesterol also plays a role in the immune system, with higher levels of HDL associated with better outcomes from parasites and bacterial infections.[ref] Genetics and HDL: HDL cholesterol levels are considered to be about half due to genes (with the rest due to diet, infection, etc.).[ref][ref] CETP gene: The CETP gene codes for the cholesteryl ester transfer protein, which moves triglycerides or cholesterol between VLDL or LDL and HDL particles

The average smoker may go through 10 to 20 cigarettes a day, depending on their habit

Heitzer T, Yl-Herttuala S, Luoma J, Kurz S, Mnzel T, Just H, Olschewski M, Drexler H