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doi: 10.1023/a:1016478708902.CrossRefGoogle Scholar Johnstone, EC, Bourne, RC, Crow, TJ, Frith, CD, Gamble, S, Lofthouse, R, Owen, F, Owens, DG, Robinson, J, Stevens, M (2002) The relationships between clinical response, psychophysiological variables and plasma levels of amitriptyline and diazepam in neurotic outpatients

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Indeed, while nicotine in normal doses is not as dangerous as perceived, the Surgeon Generals report in 2014, The Health Consequences of Smoking50 Years of Progress, surmised that nicotine has acute toxicity at high doses and activates biological pathways that upsurge the risk of disease

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