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However, despite its protective role, the constant activation of the Nfr2 pathway in response to e-cigarette use, particularly the flavouring agents found in e-cigarettes, can exhaust this protective pathway, leading to eventual cellular death in the epithelium (Ma et al

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Study author Roger Papke, a pharmacology professor in the University of Florida College of Medicine, said he wondered why the two habits seemed to go hand in hand, similar to the way people enjoy both alcohol and tobacco in the evening