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Thereby, the effectiveness of NRT in patients with mental illness is requiring a higher dose and longer duration with more intensive behavioral support [6]

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When the LES, a muscular valve located at the esophaguss end, weakens or relaxes abnormally, acidic stomach contents can travel back up into the esophagus, causing irritation and tissue damage

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Souza JDR, Pacheco JC, Rossi GN, de-Paulo BO, Zuardi AW, Guimares FS, et al