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First, hyperhomocysteinemia detected only in the fasting state (approximately 23% of patients), which might mainly result from an inhibition of the homocysteine remethylation pathway (folate, cobalamin, or functional methionine synthase deficiencies or thermolabile MTHFR mutation), and which increases the cardiovascular risk 1.6-fold

1 Selyes stress coping response The application of the Selyes stress coping response concept 22 to resolving the practical problem of arthritis, 31 resulted in the corticosteroid clinical outbreak

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