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Methods Cells and viruses Hela (female human cervix

3.2 GM and hormone metabolism disorders Hyperandrogenemia (HA) is also a pivotal clinical manifestation in patients with PCOS, potentially stemming from complex interplays involving the Hypothalamic-pituitary-gonadal (HPG) axis, adrenal function abnormalities, dysregulation of glucose and lipid metabolism, intestinal microbiota imbalances, chronic inflammation, and genetic predispositions (39)

No long term clinical human studies currently exist

We also care for many individuals with digestive disorders like Crohns disease or celiac disease, which can make it challenging to get enough B12 from diet alone

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