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Its a delicate balance

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The medication reaches steady-state concentrations after approximately four to five weeks of regular dosing, creating a stable therapeutic effect

Dulaglutide and Exenatide qw did not require any titration, and they were started at 1.5 and 2 mg from the first administration with global exposure to the specific GLP-1RA total dose of 28 weeks in both the AWARD-9 and DURATION-7