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Biochemistry 33: 3532-3539, 1994

GLP-3 might fit into combination strategies by providing complementary metabolic effects not fully achieved by GLP-1 alone, potentially enhancing specific aspects like fat oxidation or metabolic flexibility, possibly allowing lower doses of each peptide with fewer side effects, or addressing metabolic resistance that can develop with single-peptide approaches

For example, FGF studies in 1990s (Damien et al., 1993

Moreover, attenuation of endogenous GLP-1 in the VTA in the brain (Shirazi et al., 2013) increases alcohol intake in male rats

Patients with severe pancreatitis history, diabetic retinopathy requiring urgent intervention, or severe kidney disease also warrant careful risk-benefit analysis with their healthcare provider