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Gallbladder disease is associated with GLP-1based therapies like tirzepatide, particularly during rapid weight loss

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Contraindications include known hypersensitivity to mannitol (present in the formulation), active malignancy, pregnancy, disruption of the hypothalamic-pituitary axis (after surgery, radiation or major trauma), and severe hypersensitivity to any component of the lyophilized product

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[1] [2] If you are planning pregnancy, consult your healthcare provider about the appropriate timing for discontinuation and establishing alternative diabetes or weight management strategies safe for pregnancy