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Their primary biological activity is mediated by receptors belonging to the nuclear receptor superfamily, which function as transcription factors that modulate gene expression

Icariin reverses corticosterone-induced depression-like behavior, decrease in hippocampal brain-derived neurotrophic factor (BDNF) and metabolic network disturbances revealed by NMR-based metabonomics in rats

In vivo, endogenous levels of intact, biologically active peptides increase with DPP4 inhibition and are associated with improved glucose homeostasis [31,32]

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This study is supported by the Chongqing Municipal Science and Technology Bureau (N0.CSTB2022 TIAD-KPX0188)