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Why Rebound Weight Gain Can Happen After GLP-1 GLP-1 medications can lead to significant weight loss, with many people who use them consistently losing around 1520% of their body weight within a year

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Metformin is the preferred initial pharmacologic agent for treating type 2 diabetes mellitus (T2DM), and other glucose-lowering agents can be considered according to comorbidities or patient-centered treatment factors [4,5]

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