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References for the retatrutide data: Jastreboff et al., NEJM 2023: Sanyal et al., Nature Medicine 2024: Giblin et al., TRIUMPH rationale, Diabetes Obesity Metabolism 2025: How to Minimize Side Effects and Maximize Comfort GLP-1s can cause nausea, constipation, and appetite suppression

One can also consume on an empty stomach at night

The day of weekly administration can be changed, if necessary, as long as the time between the two doses is at least 3 days (72 hours) Storage General Do not freeze Zepbound

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Yerba mate is unlikely to cause harm to healthy adults who drink it occasionally