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The study is sufficiently powered when the incidence rate of the outcome of interest in the exposed individuals is significantly different from the unexposed group (Kang 2021)
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This was corroborated by a marked effect on cAMP signaling in -arrestin-less HEK293 cells, which progressively diverged with longer exendin-4 treatment, reminiscent of the effect of exendin-phe1 on beta cell cAMP production
