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Curr Opin Neurobiol 2011;21:8428

Cells were placed in 96-well cell culture plates at a density of 5000 cells/well and treated with ibrutinib in a 50 M/2 dilution series for 5 days, with 6 replicate wells per concentration

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A key feature is ECM degradation, which results from the upregulation of MMPs and ADAMTSs, leading to the breakdown of proteoglycans and collagen, ultimately causing structural damage to the intervertebral disc (36,37)

Medications with good glycemic efficacy and a low risk of hypoglycemia and weight loss help to intensify the treatment without introducing common adverse events, such as hypoglycemia and weight gain