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PLoS One 6(10):e26509 Kemper C, Oconnor D, Westlund K (1987) Immunocytochemical localization of dopamine--hydroxylase in neurons of the human brain stem

According to the results of the RCT for patients with monogenic obesity ( LEPR or POMC deficiency) and acquired hypothalamic obesity, setmelanotide can reduce body weight and inhibit appetite to a certain extent, and common adverse reactions include injection site reactions, skin hyperpigmentation, nausea, diarrhea, and abdominal pain, with occasional occurrences of sexual adverse reactions, depression, and suicidal ideation [51,52]

Some emergency responders and harm reduction groups say the threat of criminal charges can deter people from getting medical help for someone who is overdosing

Using the right technique, careful skin preparation, and switching up injection spots can help most people avoid skin irritation interfering with their progress

10.3389/fncel.2018.00329 45 GiassonB