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The results showed a significant decrease in NRF2 mRNA expression and protein levels after treatment of breast cancer cells with Vit C and Q: the nuclear/cytosolic NRF2 ratio was reduced 1.7-fold in MDA-MB 231 cells, 2-fold in MDA-MB 468 cells, 1.4-fold in MCF-7 cells, and 1.2-fold in A549 cells

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An increase in PKA activity also causes ATP-sensitive potassium channels to close, thereby depolarizing the cell membrane and opening voltage-gated calcium channels

Atkin et al., 2006)