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February 2003 study A 2003 mouse study found that TB4 in a solution or gel form promoted accelerated wound healing in healthy, diabetic, and aged mice

The clinical studies showing efficacy used concentrations in the range that produces measurable results without irritation

Heat changes tendon biology, training load tolerance shifts, and overuse injuries to the Achilles, plantar fascia, and patellar tendon are well-documented [British Journal of Sports Medicine, 2019]

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