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People with obesity often perceive tastes less intensely, and they have an inherently elevated desire for sweet and energy-dense food, said Mojca Jensterle Sever, Ph.D., of the University Medical Centre in Ljubljana, Slovenia

May cause side effects that dehydrate you, such as diarrhea : In trials for Wegovy, 30% of people on a 2.4 mg dose reported diarrhea, compared to 16% on placebo

It has been shown previously that 14% weight loss due to a very-low-energy diet (VLED) resulted in counter-regulatory changes in appetite-regulating hormones, including a significant increase in fasting levels of ghrelin and significant reductions in the fasting levels of leptin, GLP-1, peptide YY (PYY), cholecystokinin (CCK) and amylin 48

Feeling sick on semaglutide is usually related to how the medication slows digestion and affects appetite signals

For this to happen data from randomized clinical trials are necessary