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Another pre-clinical study done on C57BL/6J mice using abdominal irradiation (10 Gy) found that the expression level of miR-34a-5p in the small intestine tissue and peripheral blood significantly increased, which mediated distant cognition impairment

Activation of Nrf2 can prevent inflammatory damage and oxidative stress in the synovium via transcribing antioxidant enzymes, such as HO-1, superoxide dismutase, and GSH

10.1038/cr.2010.178 74 MorrisD.GuerraC.DonohueC.OhH.KhurasanyM.VenketaramanV

In the course of biological activities, especially within cellular energy metabolism and the biosynthesis of adenosine triphosphate (ATP), the production of ROS as a byproduct of oxygen reduction is unavoidable

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