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[1] [2] Administered as a once-weekly subcutaneous injection, Ozempic works by enhancing insulin secretion in response to elevated blood glucose, suppressing glucagon release, and slowing gastric emptying

Addressing weight gain from antipsychotics Professor Dan Siskind, a psychiatrist and lead researcher, explained that the 36-week trial demonstrated the efficacy of semaglutide in people with schizophrenia, a population often affected by weight gain as a side effect of antipsychotic medications

Additionally, tirzepatide, retatrutide, orforglipron, semaglutide, and liraglutide also showed significant weight loss effects compared to placebo

Researchers transitioning between the two should recalculate everything

Out of these, 803 participants who reached the semaglutide maintenance dose were randomized to 48 weeks of continued subcutaneous semaglutide or switched to placebo, both with lifestyle intervention