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GLP-1 from enteroendocrine cells of the intestine and a separate population of neurons in the caudal medulla oblongata acts through humoral and neural pathways, regulating the feeling of satiety, gastric peristalsis and endocrine function of the pancreas [17]

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data indicate that approximately 90% of adults meet criteria for a CKM stage, with higher prevalence in older adults and in men, and a projected further increase due to the ongoing epidemics of obesity and diabetes [147]

Which mechanisms hit hardest depends on the compound, the dose, and how aggressively intake is restricted