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Every batch is HPLC-tested by an independent external laboratory to a purity of 99% or higher, with identity confirmation via mass spectrometry
The investigators interpreted the findings as direct pharmacological validation of the NNMT-knockdown phenotype reported earlier in the Kraus 2014 genetic-validation study
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Additionally, tapering NE before reducing the AVP infusion rate could potentially prevent rebound hypotension [21, 22], although this approach is not consistently implemented, and the influence of other factors that mitigate the risk of rebound hypotension during recovery remains unclear
