10.1089/acm.2006.12.881 Summary Keywords vitamin B12, efficacy, bioavailability, therapeutic approaches, meta-analysis, cobalamin Citation Mazur M, Ndokaj A, Salerno C, Vallone J, Ardan R, Bietolini S, Carrouel F, Wilk A, Sarig R, Ottolenghi L and Bourgeois D (2025) Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis
It is not an authorised UK medicine or an established weight-management treatment
No studies have directly evaluated the cardiovascular effects of correcting vitamin B 12 deficiency in patients with known cardiovascular disease, although numerous studies have failed to demonstrate that correction of hyperhomocysteinemia itself reduces cardiovascular mortality or cardiovascular complications
Semaglutide requires **4 injections per month** compared to approximately **30 injections per month** for AOD-9604
These injections contain a synthetic version of the vitamin called cyanocobalamin and are usually given directly into a muscle by a healthcare provider
